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Hydroxyurea is taken by mouth in the form of a capsuleThe dosage and schedule is determined by the person’s size and type of cancerIt can be given alone or with other drugsIf you are having trouble swallowing this medicationcontact your provider or pharmacist for recommendations.

Many insurance companies require a prior authorization for this drugThis means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Hydroxyurea causes severe myelosuppressionTreatment with hydroxyurea should not be initiated if bone marrow function is markedly depressedBone marrow suppression may occurand leukopenia is generally its first and most common manifestationThrombocytopenia and anemia occur less often and are seldom seen without a preceding leukopeniaBone marrow depression is more likely in patients who have previously received radiotherapy or cytotoxic cancer chemotherapeutic agentsuse hydroxyurea cautiously in such patients.

Evaluate hematologic status prior to and during treatment with HYDREAProvide supportive care and modify dose or discontinue HYDREA as neededRecovery from myelosuppression is usually rapid when therapy is interrupted.

There are no data that support specific guidance for dosage adjustment in patients with hepatic impairmentClose monitoring of hematologic parameters is advised in these patients.

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